[CTD-Users] Comparative Toxicogenomics Database - December data update

[Carolyn Mattingly]

Dear CTD user,
The December update of the Comparative Toxicogenomics Database (CTD)  
is complete - you can browse our new data at http://ctd.mdibl.org.

Since last month, we added 4,123 curated interactions involving 333  
chemicals and 1,026 genes/proteins as well as 47 direct gene-disease  
relationships and 57 direct chemical-disease relationships (complete  
data statistics: http://ctd.mdibl.org/about/dataStatus.go).

Curated data were significantly increased for:
Chemicals:
Quercetin - http://ctd.mdibl.org/detail.go?type=chem&acc=D011794
Rotenone - http://ctd.mdibl.org/detail.go?type=chem&acc=D012402
Acetaldehyde - http://ctd.mdibl.org/detail.go?type=chem&acc=D000079

Genes/Proteins:
NOS2 - http://ctd.mdibl.org/detail.go?type=gene&acc=4843&db=GENE
TNF - http://ctd.mdibl.org/detail.go?type=gene&acc=7124&db=GENE
IL1B - http://ctd.mdibl.org/detail.go?type=gene&acc=3553&db=GENE

Diseases:
Lupus Erythematosus, Systemic - http://ctd.mdibl.org/detail.go?type=disease&acc=D008180&db=MESH
Fibrosis - http://ctd.mdibl.org/detail.go?type=disease&acc=D005355&db=MESH
Alcoholism - http://ctd.mdibl.org/detail.go?type=disease&acc=D000437&db=MESH

We made several additions to CTD since our last report including the  
integration of pathway data from the Reactome Database, Tag Clouds  
that provide a visual summary of highly curated data in CTD and  
mechanisms for users to request curation on specific data pages.

Finally, we're pleased to announce a new CTD publication describing a  
metric we developed to generate lists of comparable genes  
(“GeneComps”) or chemicals (“ChemComps”) based on shared toxicogenomic  
profiles:  Allan Peter Davis, Cynthia G. Murphy, Cynthia A. Saraceni- 
Richards, Michael C. Rosenstein, Thomas C. Wiegers, Thomas H. Hampton  
and Carolyn J. Mattingly. Bioinformation 4 (4):173-174 (2009).
http://www.bioinformation.net/004/003900042009.pdf

Please send us your feedback  and let us know how you are using CTD in  
your research or educational programs so we can ensure that it remains  
a valuable community resource. Look for us at the Society of  
Toxicology meeting in March.
Thanks for using CTD.

The CTD Team.


_________________________________
Carolyn J. Mattingly, PhD
Investigator
Mount Desert Island Biological Laboratory
PO Box 35
Old Bar Harbor Rd
Salisbury Cove, ME 04672

T: 207.288.9880 ext. 109
F: 207.288.2130
cmattin at mdibl.org
http://ctd.mdibl.org




-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.mdibl.org/pipermail/ctd-users/attachments/20091208/c26e9d5c/attachment.html>